what causes cushing’s disease in dogs |

Diabetes mellitus in dogs is type 1, or insulin dependent diabetes: a lack of insulin production due to destruction of pancreatic beta cells.[85][86][87] Current research indicates no evidence of type 2 diabetes in dogs.[88] Among the causes of diabetes mellitus in dogs are autoimmune disease or severe pancreatitis.[89] Forms of diabetes which may not be permanent, depending on the amount of damage to the beta cells of the endocrine pancreas,[90] are transient and secondary diabetes. Some causes of transient or secondary diabetes are Cushing’s syndrome, glucocorticoid, progestin or other steroid use, and the hormones of pregnancy or heat. In these cases, correcting the primary medical issue may mean a return to non-diabetic status.[89][91][92] Common signs include weight loss, increased drinking and urination, and cataracts. Treatment involves insulin replacement therapy,[93] and use of a diet high in fiber and complex carbohydrates.[94] Oral diabetes medications cannot be used for dogs because none repair or surmount the permanent damage to the beta cells of the pancreas.[86][95][96][97]
Prostate disease* in dogs includes benign prostatic hyperplasia (BPH), prostatitis (infection of the prostate), cancer, and cysts and abscesses. BPH is the most common and is found in older intact (not neutered) dogs. Signs include blood in the urine and straining to urinate and defecate. Castration is the treatment of choice.[157] Prostatis can be associated with BPH. Bacteria causing prostatitis include E. coli, Staphylococcus spp., Streptococcus spp., and Mycoplasma spp.[158]
Hypertrophic osteodystrophy is a bone disease in rapidly growing large breed dogs. Signs include swelling of the metaphysis (the part of the bone adjacent to the joint), pain, depression, loss of appetite, and fever. The disease is usually bilateral in the limb bones.[41]
Cocoa within chocolate contains theobromine,[34] a chemical stimulant that, together with caffeine and theophylline, belongs to the group of methylxanthine alkaloids. Dogs are unable to metabolize theobromine effectively. If they eat chocolate, the theobromine can remain in their bloodstreams for days, and dogs may experience fast heart rate, severe diarrhea, epileptic seizures, heart attacks, internal bleeding, and eventually death.[35] “One ounce of milk chocolate per pound of body weight is a potentially lethal dose in dogs.”[36] In case of accidental intake of chocolate by especially a smaller dog, contact a veterinarian or animal poison control immediately; it is commonly recommended to induce vomiting within two hours of ingestion. If chocolate ingestion is suspected (mostly dark or baking chocolate), hydrogen peroxide can be used to safely induce vomiting, then making a trip to the veterinarian is suggested. Large breeds are less susceptible to chocolate poisoning, but can still die after eating four ounces[37] of chocolate.
Cauda equina syndrome*, also known as degenerative lumbosacral stenosis, in dogs is a compression of the cauda equina by a narrowing of the lumbosacral vertebral canal. It is most commonly seen in German Shepherd Dogs. Signs include pain, weakness, and rear limb muscle atrophy.[59]
Ectropion (eyelid folding outward) is a common condition in dogs, usually affecting the lower lid. Breeds associated with ectropion include the Cocker Spaniel, the St. Bernard, the Bloodhound, and the Basset Hound.[62]
Bloat can affect any dog at any age but there are breeds more susceptible to it: usually large breed, deep-chested dogs like Great Danes, German shepherds, boxers, Labrador retrievers, bloodhounds, and weimaraners. Mid-size and smaller dogs aren’t much at risk, with the exception of basset hounds and dachshunds, who also have long, broad chests.
It takes just three weeks for one flea to turn into an infestation of 1,000 biting bugs. A very common canine health problem, fleas are easy for your dog to pick up, but they’re also easy to treat. Signs your dog may have fleas include:
Intussusception* is characterized by telescoping of one part of the gastrointestinal tract into another part, forming an obstruction. It is most common in dogs six to eight months old. Surgery is necessary for treatment.[147]
Eye diseases are common in dogs. Cataracts, canine glaucoma, and entropion are seen in dogs. Canine-specific eye diseases include progressive retinal atrophy, Collie eye anomaly, sudden acquired retinal degeneration, and cherry eye. Injury to the eye can result in corneal ulcers.
How to treat: Prevention is your best option. It starts with getting your dog shots every year. You should also monitor your dog’s activity to make sure he isn’t interacting with rabies infected animals in the wild. If you suspect that your dog has rabies, call Animal Control immediately and avoid your dog as much as possible.
Conjunctivitis* is inflammation of the conjunctiva. In dogs it is most commonly caused by mechanical irritation (such as by entropion, ectropion, or trichiasis), allergies, and keratoconjunctivitis sicca. Any bacterial infection is usually secondary.[70]
Facial nerve paralysis* is most commonly caused in dogs by trauma, otitis media, or as an idiopathic condition. Signs include an inability to blink, drooping of the ear, and drooping of the lips on the affected side, although in chronic conditions fibrosis occurs and the ear and lips may appear to be in an abnormal position.[60]
Gastrointestinal cancer* is uncommon in dogs. The most common type is lymphoma. Nonlymphomatous esophageal cancer is especially rare, the most common types being squamous cell carcinoma, adenocarcinoma, leiomyosarcoma, and osteogenic sarcoma associated with the parasite Spirocerca lupi. Nonlymphomatous stomach cancer is usually an adenocarcinoma, and nonlymphomatous intestinal cancer is usually polyps, adenomas, adenocarcinomas, leiomyosarcomas, and leiomyomas.[161]

About 4.5 million Americans receive dog bites each year, many of which require immediate medical attention. Young children 5 to 9 years old are most likely to bitten by dogs, with boys being bitten more often than girls.
Toxocara roundworms cause a parasitic disease known as toxocariasis. Dogs and people can become infected by accidentally swallowing roundworm eggs from the environment. In addition, larval worms can cross through the placenta, milk, or colostrum of a mother dog, passing the infection to her puppies. Infected puppies usually do not develop and grow well and might have a pot-bellied appearance.
Developmental orthopedic diseases include panosteitis and hypertrophic osteodystrophy. Panosteitis occurs in large and giant breed dogs usually between the age of five and fourteen months and manifests as fever, pain, and shifting leg lameness. Hypertrophic osteodystrophy is also seen in young large and giant breed dogs and is characterized by pain, lameness, fever, and swelling of the long bone metaphysis.
Congenital vertebral anomalies, including butterfly, block, and transitional vertebrae, and hemivertebrae, are a collection of malformations of the spine in animals. Most are not clinically significant, but they can cause compression of the spinal cord by deforming the vertebral canal or causing instability.[6]
The Windsor-Essex County Health Unit in southwestern Ontario announced this week it has confirmed infections in two dogs brought to Canada from South Korea by a U.S.-based dog rescue group. Both dogs have the H3N2 strain and their new owners have placed each of them into quarantine, away from other pets.
“He is soooo cute,” you thought when you first laid eyes on your dog. And—yay!—he seemed to like you too. So you brought him home—only to realize that maybe you weren’t totally prepared for the work this relationship involved. Well, your mom was right (again): Owning a dog IS a big responsibility, from training to feeding to keeping it stress-free. “We don’t have that many years with our dogs,” says Whole Dog Journal editor Nancy Kerns. Here’s how to make sure each day is filled with health—and happiness for you both.
Cryptosporidium can cause profuse, watery diarrhea with cramping, abdominal pain, and nausea in both animals and people. Illness in people is usually self-limiting and lasts only 2-4 days, but can become severe in people with weakened immune systems.
“If you live in a heartworm endemic area, which is an area with mosquitoes, heartworm prevention is a must,” Dr. Eckholm says. “There are parts of the country where mosquitoes aren’t prevalent and therefore heartworm prevention isn’t used as frequently.”
If possible, contact the owner and ensure the animal has a current rabies vaccination. You will need the rabies vaccine license number, name of the veterinarian that administered the vaccine, and the owner’s name, address, and phone number.
The frequency of bilateral glaucoma with a genetic base in purebred dogs is higher than in any species except humans.[22] Cataracts in dogs either have a genetic base or can also be caused by diabetes. Nuclear sclerosis resembles a cataract but is actually a normal age-related change.
Although a certain form of diabetes—the type found in dogs less than a year of age—is inherited, proper diet and regular exercise can go a long way to avoid the development of diabetes. Aside from other negative effects, obesity is known to contribute to insulin resistance.
Newborn puppies receive antibodies from their mothers that help provide immunity, but immunity to CPV wears off before the puppies’ immune systems are developed enough to destroy the virus and fight off infection.
Entropion (eyelid folding inward) is a common condition in dogs, especially the Chow Chow, Shar Pei, St. Bernard, and Cocker Spaniel. Upper lid entropion involves the eyelashes rubbing on the eye, but the lower lid usually has no eyelashes, so hair rubs on the eye. Surgical correction is used in more severe cases.[62]
Pasteurellosis is a bacterial disease associated with animal bites and scratches. Pasteurella is a normal bacterium that lives in the mouths of healthy dogs. The bacteria do not typically make dogs sick; however, dogs can develop abscesses or skin infections in places where they were scratched or bitten by another animal.
Urinary tract infection*, specifically cystitis or bladder infection, is common in dogs and usually caused by bacteria. Signs include blood in the urine (hematuria), difficulty urinating (dysuria), and frequent urination (polyuria).[154] The most common types of bacteria cultured from the urine of dogs with cystitis are E. coli, Staphylococcus spp., Proteus mirabilis, Streptococcus spp., Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter spp.[155]
Since the disease was first detected in 2012 in the UK the number of cases of Alabama dog rot in dogs has risen. The most serious outbreak was in the New Forest region of Hampshire but there have also been reported cases in several other counties, with the most recent cases reported Gloucestershire, Monmouthshire, Devon, Dorset, Cheshire, Warwickshire, Greater Manchester and Worcestershire.
Polyneuropathy is a collection of peripheral nerve disorders that often are breed-related in dogs. Polyneuropathy indicates that multiple nerves are involved, unlike mononeuropathy. Polyneuropathy usually involves motor nerve dysfunction, also known as lower motor neuron disease.
Jump up ^ Jansen, Barbara; Valii, Victor E. O.; Thorner, Paul; Baumal, Reuben; Lumsden, John J. (1987). “Samoyed hereditary glomerulopathy: serial, clinical and laboratory (urine, serum biochemistry and hematology) studies”. Can. J. Vet. Res. 51 (3): 387–393. PMC 1255344 . PMID 3651895.

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