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“Treatment is supportive, but is only successful in 20-30% of cases, which is why we’re encouraging all dog owners to use the online interactive guide to help them understand the clinical signs and confirmed locations of Alabama Rot.
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Jump up ^ Meurs KM1, Lahmers S, Keene BW, White SN, Oyama MA, Mauceli E, Lindblad-Toh K. A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher. Hum Genet. 2012 Aug;131(8):1319-25.
Ectropion (eyelid folding outward) is a common condition in dogs, usually affecting the lower lid. Breeds associated with ectropion include the Cocker Spaniel, the St. Bernard, the Bloodhound, and the Basset Hound.[62]
Atopy* is an allergy to a substance with which the dog is not necessarily in direct contact. It is a type I hypersensitivity to a substance that is inhaled or absorbed through the skin. Up to 10 percent of dogs are affected.[77] It is common in dogs, especially seen in breeds such as Labrador Retrievers, Golden Retrievers, and Shih Tzus. The most common symptom is itching. Affected areas include the underside, the face, the feet, and the ears.[78]
Jump up ^ “17 Products With Xylitol Which Could Kill Your Dog & Marketing Phrases Indicating Xylitol As A Possible Ingredient, Dog, Cat and other Pet Friendly Travel Articles”. www.petswelcome.com. Retrieved 2016-06-16.
^ Jump up to: a b Basso C, Fox PR, Meurs KM, et al. (March 2004). “Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of human disease”. Circulation. 109 (9): 1180–5. doi:10.1161/01.CIR.0000118494.07530.65. PMID 14993138.
Subvalvular aortic stenosis (Subaortic stenosis; SAS) is a congenital disease in dogs characterized by left ventricular outflow tract obstruction by a discrete ring or tunnel of fibrous tissue immediately below the aortic valve. It is inherited in Newfoundlands, and also found in Golden Retrievers, Rottweilers, Boxers, Bulldogs, German Shepherds, and Samoyeds. Signs include a left basilar systolic heart murmur, weak femoral pulse, fainting and exercise intolerance. Dogs with severe SAS are predisposed to dying suddenly.[49]
Thrombocytosis* is a condition characterized by an excess of platelets. Most cases are physiologic (caused by exercise) or reactive (secondary to some cancers, blood loss, or certain drugs). Rarely the condition is caused by a primary bone marrow disorder. In this last case, the platelets may not function normally, causing the blood to not clot properly.[44]
Trichiasis in dogs is hair from the eyelid growing in the wrong direction and rubbing on the eye, causing irritation. It usually occurs at the lateral upper eyelid, especially in the English Cocker Spaniel.[62]
Nutritious mass-market food abounds, says Linda Case, author of Dog Food Logic, but some of the best products come from smaller companies that make food in their own US facilities. Sure, you can feed your dog on 15 cents a day, but making the investment in higher-priced food, say at a few dollars a day, can mean the difference between giving your dog chicken and serving it ground chicken heads (yes, gross!). Tip: Grain should not be one of the first two ingredients on the label, and the protein source should be named (“trout” not “fish,” for example). Bonus: Worried about pet-food recalls? Follow the American Veterinary Medical Association on Twitter @AVMARecallWatch or its Facebook page to stay informed.
Pythiosis is a disease cause by a water mould of the genus Pythium, P. insidiosum. It occurs primarily in dogs and horses, but can also affect humans. In dogs it affects the gastrointestinal system and lymph nodes, and rarely the skin.[24]
They’re commonly known as hot spots, but the medical term for those bare, inflamed, red areas you often see on dogs is acute moist dermatitis — a bacterial skin infection. Anything that irritates your dog’s skin enough to make him scratch or chew can lead to the pain and itch of hot spots, which, if left untreated, can quickly grow larger.
For most dogs, insulin injections are necessary for adequate regulation of blood glucose. Once your pet’s individual insulin treatment is established, typically based on weight, you will be shown how to give him his insulin injections at home.
Conjunctivitis* is inflammation of the conjunctiva. In dogs it is most commonly caused by mechanical irritation (such as by entropion, ectropion, or trichiasis), allergies, and keratoconjunctivitis sicca. Any bacterial infection is usually secondary.[70]
Humans can also spread the virus by touching a dog or item contaminated with the virus and then transferring that to other dogs, says Weese, which is why it’s so important for dog owners to wash their hands after contact with a sick animal.
Hypertrophic osteodystrophy is a bone disease in rapidly growing large breed dogs. Signs include swelling of the metaphysis (the part of the bone adjacent to the joint), pain, depression, loss of appetite, and fever. The disease is usually bilateral in the limb bones.[41]
To avoid acute kidney disease, keep human medications away from your dog, unless advised otherwise by your vet. Also, keep antifreeze away from dogs; they like the taste but it’s quite poisonous, even in low doses. There are various ways dogs can get their paws on antifreeze, including licking it off the garage floor or getting it from winterized pipes.

The virus attacks rapidly-dividing cells in a dog’s body, most severely affecting the intestinal tract. Parvovirus also attacks the white blood cells, and when young animals are infected, the virus can damage the heart muscle and cause lifelong cardiac problems.
Coccidioidomycosis* is a fungal disease caused by Coccidioides immitis or Coccidioides posadasii that affects a variety of species, including dogs. In dogs signs of primary pulmonary disease include a cough, fever, weight loss, anorexia, and lethargy. Disseminated disease occurs when the fungus has spread outside of the lungs and may include clinical signs such as lameness, pain, seizures, anterior uveitis, and localized swelling.[17] Diagnosis of Valley Fever may include multiple tests, including serology and radiology. According to a study performed in the Tucson and Phoenix area, 28% of dogs will test positive for exposure to the fungus by two years of age, but only 6% of the dogs will be ill with clinical disease.[18] There is an increased risk of infection associated with amount of time spent outdoors, a larger roaming space accessed by the dog, and increasing age.[19]
Hops, a plant used in making beer, can cause malignant hyperthermia in dogs, usually with fatal results. Certain breeds, such as Greyhounds, seem particularly sensitive to hop toxicity, but hops should be kept away from all dogs. Even small amounts of hops can trigger a potentially deadly reaction, even if the hops are “spent” after use in brewing.[49]
Cases of the mystery illness have been confirmed in at least 27 counties in England and Wales since 2012, with 14 cases confirmed in 2016 alone (to end April) and possibly two further unconfirmed cases in Scotland and Northern Ireland – the first   in these two countries  
Canine glaucoma is an increase of pressure within the eye. It is a common condition in dogs. It can be caused by abnormal development of the drainage angle of the eye, lens luxation, uveitis, or cancer. Cocker Spaniels, Poodles, and Basset Hounds are predisposed.[69]
Poisoning with pain medications is common. Aspirin, paracetamol (acetaminophen, Tylenol), ibuprofen (Advil), and naproxen (Aleve) can all cause severe clinical signs in dogs, including vomiting blood, diarrhea, and abdominal pain.[57][58][59][60] Specifically, aspirin can cause metabolic acidosis and bleeding disorders, acetaminophen can cause liver disease, ibuprofen can cause kidney disease, and naproxen can cause ulcers in the stomach, which can perforate. Treatment depends on the clinical signs.
Hemolytic anemia* is a type of regenerative anemia found in dogs characterized by destruction of the red blood cell. The most important type is immune-mediated hemolytic anemia, which can be a primary disease or secondary to cancer, infection, drugs, or vaccinations. Antibodies are present on the cell surface, leading to lysis and severe anemia. Other causes of hemolytic lesion include hypophosphatemia, exposure to toxins such as lead, infections such as ehrlichiosis or babesiosis, and rarely, neonatal isoerythrolysis.[45] The behavioral condition pica, especially when involving the eating of concrete dust, tile grout, or sand, may be a sign of hemolytic anemia, indicating the need for a complete blood count to investigate a possible diagnosis.[46][47]
Ryan Rauch graduated from Scripps School of Journalism in 2009 and has been writing for Canine Journal since 2012. Ryan enjoys writing and researching new and evolving home security measures, and has a passion for technology.
Certain breeds are prone to specific cancers. Boxers, Boston terriers and Golden Retrievers are among the breeds that most commonly develop mast cell tumors or lymphoma, while large and giant breeds like Great Danes and Saint Bernards are much more likely to suffer from bone cancer than smaller breeds.
There has been some speculation that walking dogs in particular areas of the countryside may be a contributing factor, but the Forestry Commission has yet to warn of any specific sites being dangerous, reassuring dog owners by saying “Many thousands of dogs are walked in the countryside every day and it is important to remember that only a very small number of dogs have been affected.”
It is suspected the disease spreads from muddy and wooded areas – dog owners who do walk their dogs in these places are advised to wash off any mud as soon as possible, and of course, keep close control of their dogs at all times to monitor where they go.

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